Honey bee venom, or apitoxin, is a bitter colourless liquid; its active portion a mixture of proteins, which causes local inflammation and acts as an anticoagulant. Bee venom have been used in medical and cosmetic widely.
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Bee venom is a clear and watery liquid that is produced by the bodies of honeybees. It is a complex mixture of peptides, enzymes, and other bioactive molecules, including melittin, apamin, phospholipase A2, hyaluronidase, and histamine. When a bee stings, it injects its venom into the skin of its target, causing a painful and sometimes dangerous reaction. However, bee venom also has various therapeutic properties and is used in traditional medicine to treat a range of ailments, including arthritis, multiple sclerosis, and allergies.
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![Bee Poison Powder]()
Bee Poison PowderHoney bee venom, or apitoxin, is a bitter colourless liquid; its active portion a mixture of proteins, which causes local inflammation and acts as an anticoagulant.Bee venom is used by some as a treatment for rheumatism and joint...view more -
![Natural Bee Venom]()
Natural Bee VenomThe main components of bee venom are polypeptides, accounting for 70%-80% of the dry weight of bee venom, including melittin, melittin, MCD-peptides, cardiac peptides, calming peptides (saikapin), tetrapeptides (tobacco) Peptide),...view more -
![100% Natural Pure Bee Venom]()
100% Natural Pure Bee VenomHoney bee venom, or apitoxin, is a bitter colourless liquid; its active portion a mixture of proteins, which causes local inflammation and acts as an anticoagulant.Bee venom is used by some as a treatment for rheumatism and joint...view more -
![Organic Honey Bee Venom]()
Organic Honey Bee VenomBee venom is made by bees. This is the poison that makes bee stings painful.Bee venom is used to make medicine.Bee venom is used by some as a treatment for rheumatism and joint diseases due to its anticoagulant and anti-inflammatory prop...view more -
![Extract Powder Bee Venom]()
Extract Powder Bee VenomHoney bee venom, or apitoxin, is a bitter colourless liquid; its active portion a mixture of proteins, which causes local inflammation and acts as an anticoagulant.Bee venom is used by some as a treatment for rheumatism and joint...view more -
![Pure Natural Bee Venom Powder]()
Pure Natural Bee Venom PowderBee venom is made by bees. This is the poison that makes bee stings painful.Bee venom is used to make medicine.Bee venom is used by some as a treatment for rheumatism and joint diseases due to its anticoagulant and anti-inflammatory prop...view more -
![High Purity Bee Venom Powder]()
High Purity Bee Venom PowderHoney bee venom, or apitoxin, is a bitter colourless liquid; its active portion a mixture of proteins, which causes local inflammation and acts as an anticoagulant.Bee venom is used by some as a treatment for rheumatism and joint...view more -
![Pure Bee Venom Powder]()
Pure Bee Venom PowderBee venom is made by bees. This is the poison that makes bee stings painful.Bee venom is used to make medicine.Bee venom is used by some as a treatment for rheumatism and joint diseases due to its anticoagulant and anti-inflammatory prop...view more -
![Pure Bee Venom]()
Pure Bee VenomHoney bee venom, or apitoxin, is a bitter colourless liquid; its active portion a mixture of proteins, which causes local inflammation and acts as an anticoagulant.Bee venom is used by some as a treatment for rheumatism and joint...view more -
![Honey Bee Venom]()
Honey Bee VenomBee venom is made by bees. This is the poison that makes bee stings painful.Bee venom is used to make medicine.Bee venom is used by some as a treatment for rheumatism and joint diseases due to its anticoagulant and anti-inflammatory prop...view more -
![Natural Pure Bee Venom]()
Natural Pure Bee VenomMelittin is the principal toxic component of bee venom. It is a cationic, amphipathic linear peptides of high antimicrobial acivity. It is also a kinase inhibitor, selective for protein kinase C and AMP-dependent protein kinases.view more -
![Raw Material Powder Bee Venom]()
Raw Material Powder Bee VenomBee venom is made by bees. This is the poison that makes bee stings painful. Bee venom is used to make medicine. Don’t confuse bee venom with bee pollen, honey, or royal jelly.view more
May lessen arthritis-related symptoms
It has been demonstrated that rheumatoid arthritis patients can benefit from bee venom (RA). Bee venom acupuncture has been discovered to have equivalent symptom-relieving benefits to conventional RA treatments like methotrexate and celecoxib when administered daily with 5–15 bee stings. While encouraging, higher-quality research is still required to substantiate these results.
Maybe advantageous for the health of the skin
Many skin care businesses have begun using bee venom into products like serums and moisturizers. This substance may promote the health of the skin in a number of ways, including by lowering inflammation, acting as an antimicrobial, and preventing wrinkles. According to one study, using a face serum containing bee venom twice daily resulted in a significant decrease in both the depth and total number of wrinkles.
Perhaps good for immune health
It has been demonstrated that bee venom has advantageous effects on immune cells that control allergic and inflammatory reactions. Bee venom therapy has been demonstrated in animal trials to be effective in reducing inflammation and enhancing immunological function. Bee venom therapy may aid in the treatment of allergic disorders including asthma, according to other animal research.
May heal neurological conditions
Although there are few trials on humans, some research indicates that bee venom therapy may help lessen symptoms of neurological illnesses, such as Parkinson's disease.
Alleviates discomfort
One study found that patients with persistent low back pain who both had conventional medication therapy and bee venom acupuncture saw a significant pain reduction and improvement in functional status.
Types of Bee Venom
Pure Raw Queen Bee Larva Powder
Queen Bee Larva Powder is comprised of queen bee larvae that have been freeze-dried, then refined into a light tan powder. This product is obtained from pure fresh good queen bee larva by procession of low temperature freeze drying.This product is most commonly used as a functional food additive.
Natural Queen Bee Larvae Lyophilized Powder
Under the action of tyrosinase, tyrosine will be oxidized in contact with air for half an hour and turn the insect body black. Meanwhile, the queen bee larva has high water content, rich nutrition and is prone to microorganisms and corruption.
Queen Bee Larva Powder
The queen is the only fertile female within a honeybee colony and is responsible for maintaining a strong population of worker bees in the hive. The difference of queen and worker bee larva arises from a variation in diet.
Queen Bee Larva
Queen bee queen larvae tire means is bees reproduce natural products. Contains extremely rich in protein, amino acids, minerals, trace elements and vitamins, especially vitamin D 10 times than cod liver oil Vd content. This product is made of high quality queen tires as raw material, -40 ℃ low temperature freeze-dried crushed and refined.
Queen Larva Powder
The queen bee embryo is a vegetative living organism at this stage from the hatching of the queen bee's egg to the three days before the larva seals and becomes pupa. It's a natural product of bee colonies.
Application of Bee Venom
Bee venom (BV) has been used for medicinal purposes for centuries. The venom is a cocktail of active components that have been shown to have anti-inflammatory, analgesic, and immunomodulatory effects. Here are some applications of bee venom:
Arthritis
BV has been shown to reduce inflammation and pain associated with arthritis. A 2015 study found that BV reduces pain and stiffness in patients with osteoarthritis of the knee.
Multiple Sclerosis
BV has been shown to have a positive effect on the symptoms of multiple sclerosis (MS). In a 2014 study, patients with MS who received BV showed an improvement in their symptoms compared to those who received a placebo.
Pain Relief
BV has been shown to have analgesic effects, which can provide pain relief for a variety of conditions, including back pain, joint pain, and migraines.
Skin Care
BV has been used in skin care products due to its anti-inflammatory and anti-aging properties. It has been shown to reduce the appearance of fine lines and wrinkles, and to improve skin elasticity.
Cancer Treatment
Some studies have suggested that BV may have anti-cancer properties. It has been shown to induce cell death in some cancer cells, and to inhibit the growth of others.
Allergies
BV has been used to treat allergies, as it has been shown to stimulate the immune system and reduce the severity of allergic reactions.
Immune System Boost
BV has been shown to stimulate the production of immune cells, which can strengthen the immune system and help fight off infections.
What Are the Components of Bee Venom?
Polypeptides
The main components of bee venom are polypeptides (about 70-80% of bee venom dry matter), such as melittin, melittin, MCD peptide, heart peptide, cycarpine, tropin, etc., of which melittin (about 50% of bee venom dry matter) and melittin (about 3% of bee venom dry matter) are the most abundant. Melittin has anti-inflammatory, antihypertensive, analgesic, antibacterial, anti-radiation and anti-tumor effects, while melittin has inhibitory nervous excitation, anti-arrhythmia, improve microcirculation, anti-inflammatory and immunomodulatory effects.
Enzymes
There are at least 50 kinds of enzymes in bee venom, such as hyaluronidase, phospholipase (including phospholipase A1, phospholipase A2, etc.), lipase, glucosidase, amidase, etc., among which hyaluronidase (accounting for about 1-3% of bee venom dry matter) and phospholipase (accounting for about 1-2% of bee venom dry matter) are most abundant. Hyaluronidase has a strong biological activity and can promote the diffusion and penetration of other components of bee venom in the body, while phospholipase can decompose lecithin and has a strong role in hemolysis and immune function.
Amines
Bee venom is rich in amines (accounting for about 1% of the dry matter of bee venom), such as histamine, dopamine, putrescine, spermine, spermine, etc. The most representative amines are histamine and dopamine. Histamine can affect the response of many kinds of cells, and has the effects of dilating blood vessels, lowering blood pressure, causing allergy and regulating immune function, while dopamine is the precursor of norepinephrine. It has the function of adrenergic α and β receptors, and also acts on the dopamine receptors of the kidney, mesenteric blood vessels and coronary arteries
Amino acid
Bee venom contains a certain amount of free amino acids such as leucine, glutamic acid, tryptophan, proline, arginine, aspartic acid, histidine, lysine, etc., of which leucine (about 0.3% of bee venom dry matter) and glutamic acid (about 0.3% of bee venom dry matter) have the highest content. Leucine, together with isoleucine and valine, can repair muscles, control blood sugar and provide energy, while glutamate plays an important role in protein metabolism and participates in many important chemical reactions in the body.
How Bee Venom Is Produced?
As we all know, the main difference between bees and other insects lies precisely in the fact that when the bee decides to sting it does so in extreme cases because when the bee uses its sting it goes against the death. Whenever the bee stings, its sting remains stuck in the skin of the subject that has suffered the sting and, the detachment of the sting also determines the detachment of some internal organs of the animal which leads to death.
To extract the bee venom without the animal dying, some special methods are used that protect the life of the insect and do not cause damage. As we all know, bees must be protected as they play an important role in our ecosystem
From the production of honey to protect biodiversity, bees are an important element for our planet.
Bee venom can therefore be extracted by inserting a device into the hive that releases electric shocks and pushes the bees to sting to defend themselves, in order to release the poison. However, their sting remains well anchored and the extraction does not cause their death.
How Safe Are Bees When Harvesting Bee Venom?
Bees are absolutely safe; we are cooperating with beekeepers having very big experience in safe harvesting bee venom. They know how many times, at what time and weather, and what level of electricity to use while collecting bee venom. Big experience and special knowledge is necessary in order to collect bee venom and not causing harm to bees. Bees’ health is the most important for us, as only healthy bees can grant us strong, high activity of bee venom powder.
The Skincare Benefits of Bee Venom
Botox in a bottle
Bee venom rose to fame when people realised that it could be a natural alternative to botox. Thanks to the fact that it stimulates collagen and elastin production, your skin feels tighter, smoother, younger, and more lifted—it reduces and smoothens the appearance of fine lines and wrinkles. Bee venom also encourages skin cell renewal, making skin appear healthier and youthful too. Plus, considering the venom acts like anaphylactic, it provides a temporary relaxing effect to your facial muscles, which leaves you with tighter skin.
Acne fighter
Melittin, one of the active compounds found in bee venom, has several anti-bacterial and anti-inflammatory effects. Although this very compound is what causes the inflammation and pain when you get stung by a bee, in small doses it tends to have an anti-inflammatory effect, thus helping treat mild to moderate acne.
Treats eczema & psoraisis
Eczema and psoriasis are inflammatory skin conditions and thanks to the melittin present in bee venom, it can help reduce the severity of these conditions, and prevent itching and redness.
Does the Color of Bee Venom Define the Quality of Bee Venom?
Color is not a measure of quality. Color maybe pale gray, human skin color, light yellow and brownish. It depends on the technique of harvesting, time of harvesting and race of bees. However, if bee venom is 5 or more years old, it becomes dark brown, because of the damaged cells of proteins and enzymes.
How Bee Venom in Skincare Can Help Eczema?
Eczema is an inflammatory condition, but bee venom can help here, too. Several studies have found that bee venom can reduce both the number and severity of dry skin patches caused by eczema, plus it significantly reduces the itching associated with the condition. An emollient, basically a medical moisturiser, containing bee venom can also reduce levels of inflammation in the skin, which may also limit the number of flare-ups.
Factors Affecting Quality of Honey Bee Venom
Bee species and genetics
The quality and quantity of venom can vary based on the species and genetics of the bees. For instance, Apis mellifera bees are known to have potent venom, while other species may produce less toxic venom.
01
Age and health of bees
The venom gland of the bee develops as it ages and gains nutritional and immune system resources. Older and healthier bees are known to produce more potent venom compared to younger or sickly bees.
02
Environment
Environmental factors such as temperature, humidity, and access to food sources can affect the quality and quantity of venom. Bees that have access to high-quality nectar and pollen are generally healthier and can produce higher quality venom.
03
Seasonality
The seasonality of beekeeping can influence the quality of venom. Bees produce more potent venom during the active season, such as summer and spring, compared to the inactive season, such as winter.
04
Extraction method
The method used to extract venom can also impact its quality. Bee venom collected through electrical stimulation is generally considered to be of higher quality than manually extracted venom.
05
Bee venom components were reported to have a wide variety of pharmaceutical properties. Due to its anticoagulant and anti-inflammatory properties in apitherapy bee venom was mainly used to treat many inflammatory disorders such as arthritis, bursitis, tendinitis, dissolving scar tissue, herpes, joint disease, rheumatoid arthritis, Lyme disease, Multiple Sclerosis and osteoarthritis. Furthermore, research in various animal experimental models with inflammatory diseases demonstrated that Bee venom administration was successfully effective in suppressing the inflammation. Several studies prove that bee venom PLA2 and melittin may be a new therapeutic approach to treatment of Alzheimer Parkinson diseases.
Here is the list of diseases and health problems improved or healed according to various reports: Arthritis, many types, Multiple scleroses, migraine, some types of cancer, neuralgia, malaria, skin problems, such as acne, psoriasis, liver fibrosis, and atherosclerosis. At present, In vitro study of Parkinson’s disease is being conducted as well as multiple sclerosis, psoriasis treatment Developed PLA2 as a therapeutic agent for autoimmune diseases as a new natural drug isolated from natural bee venom.
The most important research of last years was studies about bee venom melittin as a potential key in HIV treatment. Toxin melittin can potentially destroy HIV and last year corona virus pandemic news is, using bee venom in treatment of Covid-19 and information about its effect in vitro and in vivo.
How to Store Bee Venom?
Bee venom is a colorless fluid, but it becomes a white powder after drying. Remove it from the glass plate with a scraper as soon as possible and store it in a dark glass jar. If you don't, it will oxidate, and the color will change to dark yellow. A good way to store it would be putting bee venom in a freezer, but freeze-drying is probably the most effective method of preserving bee venom. The better and sooner you store it properly, the more active ingredients it will have, and the better price it will get on the market.
When to collect bee venom?
You should collect bee venom during the spring-summer season.
Some people prefer to collect bee venom during the day, while others during the night. As mentioned before, collecting during the NIGHT could potentially be a very efficient way of collecting bee venom, because this is the time when most bees are inside the hive. However, collecting during the night might be extremely tricky for you and the bees; the bees are more agitated during the night, so they are more likely to sting you and die. You could set up everything the day before and turn on the collectors during the night, but if you leave the collected venom overnight in the hive, it might oxidate and lose quality, which means a lower price for you ( if you want to sell bee venom).
We collect during the DAY, from morning till evening. In our opinion, collecting during the day is the best because it allows observing the bees during the collection process and adjusting the bee venom collecting box (time-frequency and voltage) as necessary. Collecting bee venom isn't a job for someone who wants to turn on the collector, leave, and return after a certain period of time; this way you wouldn't yield the maximum amount of bee venom, only a certain part of that.
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Hangzhou Golden Harvest Health Industry Co., Ltd. is located in Hangzhou city, Zhejiang province,which is knows as”China bee products base", founded in 2004, Golden harvest is a professional bee products company, focusing on bee products, our main products are honey,beeswax, royal jelly,propolis,and bee pollen. Adhering to the "to provide pure natural products for your healthy life" as mission;top quality as basic requirements; "integrity, partnerships and win-win" as development ideas, with years of sales experience,quality products & perfect services,we have won a high reputation and are trusted by customers from both at home and abroad.
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